Cancer chemotherapy with indole-3-carbinol, bis(3′-indolyl)methane and synthetic analogs
نویسندگان
چکیده
منابع مشابه
Indole-3-Carbinol Monograph
Introduction Indole-3-carbinol (I3C) is a compound found in high concentrations in Brassica family vegetables, including broccoli, cauliflower, Brussels sprouts, and cabbage. As a nutritional supplement, I3C has received attention in recent years as a promising preventive and treatment agent for breast and other types of cancers, and may have beneficial effect in the management of Herpes simple...
متن کاملPrevention and treatment of cancer with indole-3-carbinol.
Indole-3-carbinol (I-3-C) is a naturally occurring constituent of many plant foods. Oral administration of I-3-C has been shown to manipulate estrogen metabolism in humans in a possibly beneficial manner. I-3-C increases the 2/16-hydroxyestrone ratio, a ratio found to be predictive of breast cancer risk in some prospective studies. Animal and in vitro studies have identified a number of other p...
متن کاملIndole-3-carbinol as a chemopreventive and anti-cancer agent.
During the course of oncogenesis and tumor progression, cancer cells constitutively upregulate signaling pathways relevant to cell proliferation and survival as a strategy to overcome genomic instability and acquire resistance phenotype to chemotherapeutic agents. In light of this clinical and molecular heterogeneity of human cancers, it is desirable to concomitantly target these genetic abnorm...
متن کاملIndole-3-carbinol inhibits nasopharyngeal carcinoma.
This study explored the effects of indole-3-carbinol on the proliferation of human nasopharyngeal carcinoma, both in vitro and in vivo, and the underlying mechanisms in inducing apoptosis of CNE1 cells. Proliferation, apoptosis, malondialdehyde, superoxide dismutase, glutathione peroxidase, expressions of caspase-9, and caspase-3 in human nasopharyngeal carcinoma cells CNE1 were examined. Indol...
متن کاملThe Synergistic Apoptotic Interaction of Indole-3-Carbinol and Genistein with TRAIL on Endometrial Cancer Cells
Induction of apoptosis in target cells is a key mechanism by which chemotherapy promotes cell killing. The purpose of this study was to determine whether Indole-3-Carbinol (I3C) and Genistein in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induce apoptosis in endometrial cancer cell (Ishikawa) and to assess apoptotic mechanism. The MTT assay and flow cytometr...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2008
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2008.04.021